Dolgic LQ Oral

Generic Name: butalbital, acetaminophen, and caffeine (Oral route)

bue-TAL-bi-tal, a-seet-a-MIN-oh-fen, KAF-een

Oral route(Tablet)

Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg/day, and often involve more the one acetaminophen-containing product

Commonly used brand name(s)

In the U.S.

• Anolor 300


• Dolgic LQ


• Esgic


• Esgic-Plus


• Ezol


• Fioricet


• Geone


• Margesic


• Medigesic


• Nonbac


• Pacaps


• Repan

Available Dosage Forms:

• Capsule


• Tablet


• Solution

Therapeutic Class: Butalbital/Acetaminophen Combination

Pharmacologic Class: Barbiturate

Chemical Class: Methylxanthine

Uses For Dolgic LQ

Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches.

Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

Caffeine is a CNS stimulant that is used with pain relievers to increase their effect. It has also been used for migraine headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it.

This medicine is available only with your doctor's prescription.

Before Using Dolgic LQ

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of butalbital, acetaminophen, and caffeine combination in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of butalbital, acetaminophen, and caffeine combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving butalbital, acetaminophen, and caffeine combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Anisindione


• Aprobarbital


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Diazepam


• Dicumarol


• Estazolam


• Ethchlorvynol


• Fentanyl


• Flunitrazepam


• Flurazepam


• Halazepam


• Hydrocodone


• Hydromorphone


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenindione


• Phenobarbital


• Phenprocoumon


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Quetiapine


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Temazepam


• Thiopental


• Triazolam

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Cannabis


• Carbamazepine


• Imipramine


• Isoniazid


• Phenytoin


• Prednisone


• Warfarin


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Cabbage


• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, history of or


• Drug dependence, or history of or


• Weakened physical condition—Use with caution. May increase risk for more serious side effects.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Porphyria (an enzyme problem)—Should not be used in patients with this condition.

• Stomach problems—Use with caution. May make these conditions worse.

Proper Use of butalbital, acetaminophen, and caffeine

This section provides information on the proper use of a number of products that contain butalbital, acetaminophen, and caffeine. It may not be specific to Dolgic LQ. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming and cause mental or physical dependence. Also, large amounts of acetaminophen may cause liver damage if taken for a long time.

Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For tension headaches:
    
    • Adults, teenagers, and children 12 years of age—One or two tablets every 4 hours as needed. However, the dose is usually not more than 6 tablets per day. Do not exceed 4 grams (4000 milligrams) of acetaminophen (Tylenol (R)) per day.
    
    
    • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Dolgic LQ

It is very important that your doctor check your progress while you or your child are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

This medicine may make you dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.

Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Dolgic LQ Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Lightheadedness


• shortness of breath

Incidence not known

• Abdominal or stomach pain


• black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• blood in the urine or stools


• blurred vision


• change in the frequency of urination or amount of urine


• chills


• cough


• diarrhea


• difficulty with breathing


• difficulty with swallowing


• dizziness


• drowsiness


• dry mouth


• fainting


• fast heartbeat


• fast, pounding, or irregular heartbeat or pulse


• flushed or dry skin


• fruit-like breath odor


• hives


• increased hunger


• increased thirst


• increased urination


• itching


• joint or muscle pain


• loss of appetite


• nausea or vomiting


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• seizure


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• sweating


• swelling of the feet or lower legs


• tightness in the chest


• trembling or shaking of the hands or feet


• troubled breathing


• unexplained weight loss


• unusual bleeding or bruising


• unusual tiredness or weakness


• weakness


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Confusion as to time, place, or person


• dark urine


• difficult or painful urination


• difficult or troubled breathing


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fever


• general feeling of discomfort or illness


• hallucinations


• headache


• holding false beliefs that cannot be changed by fact


• increased sweating


• irregular, fast or slow, or shallow breathing


• light-colored stools


• loss of appetite


• pale or blue lips, fingernails, or skin


• restlessness


• sleeplessness


• sudden decrease in the amount of urine


• sweating


• trouble sleeping


• unable to sleep


• unpleasant breath odor


• unusual excitement, nervousness, or restlessness


• vomiting of blood


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Relaxed and calm


• sleepiness

Incidence not known

• Anxiety


• bloated


• constipation


• continuing ringing or buzzing or other unexplained noise in the ears


• depression


• earache


• excess air or gas in the stomach or intestines


• false or unusual sense of well-being


• full feeling


• hearing loss


• heartburn


• heavy eyelids


• high energy


• hot spells


• hyperventilation


• irritability


• numbness


• pain in the leg


• passing gas


• sluggishness


• stuffy nose


• tingling sensation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Loranka

Loranka may be available in the countries listed below.

Ingredient matches for Loranka

Lormetazepam

Lormetazepam is reported as an ingredient of Loranka in the following countries:

• Belgium


• Luxembourg

International Drug Name Search

Ortho-Cept

Pronunciation: des-oh-JES-trel/ETH-in-il ess-trah-DYE-ole
Generic Name: Desogestrel/Ethinyl Estradiol
Brand Name: Examples include Desogen and Ortho-Cept

Cigarette smoking while taking Ortho-Cept increases the risk of serious heart problems. The risk increases with age (over 35 years of age) and with heavy smoking (15 or more cigarettes per day). Patients who use Ortho-Cept are strongly advised not to smoke.

Ortho-Cept is used for:

Preventing pregnancy. It may also be used for other conditions as determined by your doctor.

Ortho-Cept is an estrogen/progestin combination. It works by preventing the release of eggs from the ovaries and thereby preventing pregnancy.

Do NOT use Ortho-Cept if:

• you are allergic to any ingredient in Ortho-Cept


• you are pregnant or think you may be pregnant


• you have blood clots in the legs, lungs, or eyes; or a history of heart attack, chest pain, or stroke


• you have known or suspected breast cancer or cancer of the lining of the uterus, cervix, or vagina, or have had vaginal bleeding of unknown causes


• you have a liver tumor or active liver disease, or a history of yellowing of the eyes or skin during pregnancy or previous birth control use


• you have headaches with neurological symptoms or will be on bed rest for a long period following surgery

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ortho-Cept:

Some medical conditions may interact with Ortho-Cept. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have high blood pressure; high cholesterol, triglycerides, or calcium levels; have pancreatitis or gallbladder problems; or are obese


• if you have breast nodules, fibrocystic disease of the breast, an abnormal breast x-ray or mammogram, endometriosis or endometrial carcinomas, uterine fibroids, or irregular or scanty menstrual periods


• if you have diabetes, headaches, migraine headaches, epilepsy, or a history of mental depression


• if you are having surgery


• if you are a heavy smoker (15 or more cigarettes per day), especially if you are older than 35 years of age

Some MEDICINES MAY INTERACT with Ortho-Cept. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Azole antifungals (eg, itraconazole), aprepitant, bosentan, barbiturates (eg, phenobarbital), carbamazepine, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), rifampin, St. John's wort, tetracyclines (eg, doxycycline), topiramate, and troglitazone because they may decrease the effectiveness of Ortho-Cept. Alternative forms of birth control are strongly recommended when taking any of these medicines along with this birth control medicine.


• Beta-blockers (eg, atenolol), selegiline, theophyllines (eg, aminophylline), and troleandomycin because the risk of their side effects may be increased by Ortho-Cept


• Lamotrigine because its effectiveness may be decreased by Ortho-Cept

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ortho-Cept may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ortho-Cept:

Use Ortho-Cept as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ortho-Cept by mouth with or without food.


• To achieve maximum effectiveness of Ortho-Cept, it must be taken every day (every 24 hours) and at the same time each day.


• Remember to take all of the pills in the pack. Do not skip any doses.


• Be sure to have an extra full pack of this medication available at all times.


• If you miss 1 dose of Ortho-Cept, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. You do not need to use a backup method of birth control if you only miss 1 pill. If you miss more than 1 active dose of Ortho-Cept, read the extra patient information leaflet that comes with Ortho-Cept or contact you doctor for instructions. You must use a backup method of birth control if you miss more than 1 active dose of Ortho-Cept. If you are not sure about how to handle missed doses, use an extra form of birth control (eg, condoms) and talk with your doctor.

Ask your health care provider any questions you may have about how to use Ortho-Cept.

Important safety information:

• Ortho-Cept may cause dizziness or changes in vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ortho-Cept with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant.


• Ortho-Cept may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.


• Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.


• Ortho-Cept may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Ortho-Cept.


• If you will be having surgery or will be confined to a chair or bed for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks beforehand. Special precautions may need to be taken in these circumstances while you are taking Ortho-Cept.


• Bleeding or spotting may occur while taking Ortho-Cept. Do not stop taking Ortho-Cept if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor.


• Ortho-Cept may increase the risk of stroke, heart attack, blood clots, high blood pressure, or similar problems. The risk may be greater if you smoke.


• Taking certain antibiotics or anticonvulsants while you are using Ortho-Cept, or vomiting or diarrhea may decrease the effectiveness of Ortho-Cept. To prevent pregnancy, use an additional form of birth control (such as condoms, spermicide, diaphragm) until your next period. If you have any questions, contact your doctor, nurse, or pharmacist.


• If you wear contact lenses and you develop problems with them, contact your doctor.


• Use of Ortho-Cept will not prevent the spread of sexually transmitted diseases (STDs).


• Lab tests, may be performed while you use Ortho-Cept. These tests may be used to monitor your condition or check for side effects. You will need to have follow-up exams at least once per year. Be sure to keep all doctor and lab appointments.


• Ortho-Cept should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Ortho-Cept if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Continue to use another method of birth control (such as condoms). Ortho-Cept is found in breast milk. Do not breast-feed while you are taking Ortho-Cept. Do not take Ortho-Cept soon after delivery of a baby even if you are not breast-feeding. You should wait 4 weeks after delivery if you are not breast-feeding or 4 weeks after a second trimester abortion.

Possible side effects of Ortho-Cept:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; loss of scalp hair; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast lumps; calf/leg pain or swelling; changes in vision; chest pain or heaviness in the chest; coughing up blood; difficulty wearing contact lenses; dark urine or light-colored bowel movements; dizziness or fainting; fever; loss of appetite; missed menstrual period; mood/mental changes; numbness of an arm or leg; persistent or recurrent abnormal vaginal bleeding; severe pain or tenderness in the stomach area; shortness of breath; sleeplessness; slurred speech; sudden severe headache (migraine); sudden shortness of breath; swelling of fingers or ankles; vaginal infection; vomiting; weakness or fatigue; weakness or numbness in the arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ortho-Cept side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms of overdose may include nausea or vomiting; vaginal bleeding.

Proper storage of Ortho-Cept:

Store Ortho-Cept at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ortho-Cept out of the reach of children and away from pets.

General information:

• If you have any questions about Ortho-Cept, please talk with your doctor, pharmacist, or other health care provider.


• Ortho-Cept is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ortho-Cept. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ortho-Cept resources

• Ortho-Cept Side Effects (in more detail)
• Ortho-Cept Use in Pregnancy & Breastfeeding
• Drug Images
• Ortho-Cept Drug Interactions
• Ortho-Cept Support Group
• 2 Reviews for Ortho-Cept - Add your own review/rating

• Ortho-Cept Prescribing Information (FDA)


• Apri Prescribing Information (FDA)


• Caziant Prescribing Information (FDA)


• Cesia Prescribing Information (FDA)


• Cyclessa Prescribing Information (FDA)


• Cyclessa Advanced Consumer (Micromedex) - Includes Dosage Information


• Desogen Consumer Overview


• Desogen Prescribing Information (FDA)


• Emoquette Prescribing Information (FDA)


• Kariva Prescribing Information (FDA)


• Mircette Consumer Overview


• Mircette Prescribing Information (FDA)


• Reclipsen Prescribing Information (FDA)


• Solia Prescribing Information (FDA)


• Velivet Prescribing Information (FDA)

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• Abnormal Uterine Bleeding
• Birth Control
• Endometriosis
• Gonadotropin Inhibition
• Polycystic Ovary Syndrome

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