OxyIR

Pronunciation: ox-ee-KOE-dohn
Generic Name: Oxycodone
Brand Name: Examples include OxyIR and Roxicodone

OxyIR is used for:

Treating moderate to severe pain. It may be used before surgery to sedate the patient and reduce fear. It may also be used for other conditions as determined by your doctor.

OxyIR is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, respiratory and circulatory systems) at higher doses.

Do NOT use OxyIR if:

• you are allergic to any ingredient in OxyIR or any other oxycodone- or morphine-related medicine (eg, codeine)


• you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days


• you have severe bowel motility problems (eg, paralytic ileus) or severe diarrhea associated with antibiotic use (pseudomembranous colitis)


• you have severely slow or difficult breathing or severe asthma, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using OxyIR:

Some medical conditions may interact with OxyIR. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems


• if you have a history of recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or seizures


• if you have a history of heart problems, low blood pressure, liver or kidney problems, an underactive thyroid, adrenal gland problems (eg, Addison disease), stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria


• if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with OxyIR. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cimetidine, furazolidone, MAO inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), or sodium oxybate (GHB) because the risk of side effects such as severe drowsiness, slow or difficult breathing, confusion, and seizures may be increased


• Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of OxyIR may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if OxyIR may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use OxyIR:

Use OxyIR as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take OxyIR by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you miss a dose of OxyIR and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use OxyIR.

Important safety information:

• OxyIR may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use OxyIR with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using OxyIR; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• OxyIR may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Tell your doctor or dentist that you take OxyIR before you receive any medical or dental care, emergency care, or surgery.


• Use OxyIR with caution in the ELDERLY; they may be more sensitive to its effects.


• OxyIR should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using OxyIR while you are pregnant. OxyIR is found in breast milk. Do not breast-feed while taking OxyIR.

When used for long periods of time or at high doses, OxyIR may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if OxyIR stops working well. Do not take more than prescribed.

Some people who use OxyIR for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you suddenly stop taking OxyIR, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of OxyIR:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: OxyIR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold and clammy skin; confusion; loss of consciousness; seizures; severe drowsiness, dizziness, or lightheadedness; slow breathing; slow heartbeat.

Proper storage of OxyIR:

Store OxyIR at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from light, heat, and moisture. Do not store in the bathroom. Keep OxyIR out of the reach of children and away from pets.

General information:

• If you have any questions about OxyIR, please talk with your doctor, pharmacist, or other health care provider.


• OxyIR is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about OxyIR. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More OxyIR resources

• OxyIR Side Effects (in more detail)
• OxyIR Use in Pregnancy & Breastfeeding
• Drug Images
• OxyIR Drug Interactions
• OxyIR Support Group
• 3 Reviews for OxyIR - Add your own review/rating

• Dazidox Advanced Consumer (Micromedex) - Includes Dosage Information


• OxyContin Prescribing Information (FDA)


• Oxycodone Prescribing Information (FDA)


• Oxycodone Monograph (AHFS DI)


• Oxycontin Consumer Overview


• Roxicodone Prescribing Information (FDA)

Compare OxyIR with other medications

• Pain

Safexin

Safexin may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Safexin

Cefalexin

Cefalexin sodium salt (a derivative of Cefalexin) is reported as an ingredient of Safexin in the following countries:

• Italy

International Drug Name Search

Strongid

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Strongid

Pyrantel

Pyrantel embonate (a derivative of Pyrantel) is reported as an ingredient of Strongid in the following countries:

• Finland


• France


• Ireland


• Italy


• Netherlands


• Portugal


• Switzerland


• United Kingdom


• United States

Pyrantel tartrate (a derivative of Pyrantel) is reported as an ingredient of Strongid in the following countries:

• United States

International Drug Name Search

Propranolol Lek

Propranolol Lek may be available in the countries listed below.

Ingredient matches for Propranolol Lek

Propranolol

Propranolol hydrochloride (a derivative of Propranolol) is reported as an ingredient of Propranolol Lek in the following countries:

• Croatia (Hrvatska)

International Drug Name Search

brimonidine ophthalmic

Generic Name: brimonidine ophthalmic (bri MO ni deen)

Brand names: Alphagan P, Alphagan

What is brimonidine ophthalmic?

Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Brimonidine ophthalmic is used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about brimonidine ophthalmic?

Do not use brimonidine ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using brimonidine ophthalmic, tell your doctor if you have kidney or liver disease, heart disease, high blood pressure, circulation problems such as Raynaud's or Buerger's disease, or a history of fainting or low blood pressure.

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using brimonidine before putting your contact lenses in.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

What should I discuss with my healthcare provider before using brimonidine ophthalmic?

You should not use this medication if you are allergic to brimonidine.

Do not use brimonidine ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using brimonidine ophthalmic, tell your doctor if you have:

• kidney disease;


• liver disease;


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  circulation problems, such as Raynaud's syndrome or Buerger's disease; or

  
  


• 
  

  a history of fainting or low blood pressure.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely use brimonidine ophthalmic.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether brimonidine ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use brimonidine ophthalmic?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before using the eye drops.

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using brimonidine before putting your contact lenses in.

To apply the eye drops:

• 
  

  Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

  
  


• 
  

  Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct.

  
  


• 
  

  If you use any other eye medications, wait about 5 minutes after using brimonidine eye drops before using the other medication.

  
  


• 
  

  Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

  
  

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Store the drops at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. An overdose of brimonidine ophthalmic is unlikely to cause life-threatening side effects.

What should I avoid while using brimonidine ophthalmic?

Brimonidine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid using any eye medications your doctor has not prescribed. Cold or allergy medicine, narcotic pain medicine, sleeping pills, sedatives, and medicine for seizures can add to sleepiness caused by brimonidine ophthalmic. Tell your doctor if you regularly use any of these medicines.

Brimonidine ophthalmic side effects

Stop using brimonidine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  slow or uneven heart rate;

  
  


• 
  

  pounding heartbeats or fluttering in your chest;

  
  


• 
  

  shallow breathing, feeling like you might pass out;

  
  


• 
  

  severe swelling, redness, or discomfort in or around your eye;

  
  


• 
  

  eye pain or increased watering; or

  
  


• 
  

  numbness or tingly feeling in your hands or feet.

  
  

Less serious side effects may include:

• 
  

  burning, stinging, or itching of your eyes;

  
  


• 
  

  feeling like something is in your eye;

  
  


• 
  

  blurred vision;

  
  


• 
  

  redness of the eye or eyelid;

  
  


• 
  

  mildly swollen or puffy eyes;

  
  


• 
  

  sensitivity to light;

  
  


• 
  

  nausea, upset stomach;

  
  


• 
  

  headache, dizziness;

  
  


• 
  

  muscle pain;

  
  


• 
  

  tired feeling;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  dry nose or mouth; or

  
  


• 
  

  unusual or unpleasant taste in your mouth.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Brimonidine ophthalmic Dosing Information

Usual Adult Dose for Intraocular Hypertension:

1 drop in the affected eye every 8 hours

Usual Adult Dose for Glaucoma (Open Angle):

1 drop in the affected eye every 8 hours

Usual Pediatric Dose for Intraocular Hypertension:

>= 2 years: 1 drop in the affected eye every 8 hours

Usual Pediatric Dose for Glaucoma (Open Angle):

>= 2 years: 1 drop in the affected eye every 8 hours

What other drugs will affect brimonidine ophthalmic?

Before using brimonidine ophthalmic, tell your doctor if you are using any of the following medications:

• 
  

  blood pressure medications;

  
  


• 
  

  digoxin (digitalis, Lanoxin);

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), betaxolol (Betoptic, Kerlone), bisoprolol (Zebeta), carteolol (Cartrol, Ocupress), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Betimol, Blocadren, Cosopt, Timoptic, Istalol), and others; or

  
  


• 
  

  antidepressants such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.

  
  

This list is not complete and there may be other drugs that can interact with brimonidine ophthalmic. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More brimonidine ophthalmic resources

• Brimonidine ophthalmic Side Effects (in more detail)
• Brimonidine ophthalmic Dosage
• Brimonidine ophthalmic Use in Pregnancy & Breastfeeding
• Brimonidine ophthalmic Drug Interactions
• Brimonidine ophthalmic Support Group
• 3 Reviews for Brimonidine - Add your own review/rating

• Alphagan Consumer Overview


• Alphagan P Prescribing Information (FDA)


• Alphagan P Monograph (AHFS DI)


• Alphagan P Advanced Consumer (Micromedex) - Includes Dosage Information


• Alphagan P MedFacts Consumer Leaflet (Wolters Kluwer)

Compare brimonidine ophthalmic with other medications

• Glaucoma, Open Angle
• Intraocular Hypertension

Where can I get more information?

• Your pharmacist can provide more information about brimonidine ophthalmic.

See also: brimonidine side effects (in more detail)